Clinical Evidence


An open-label single-arm, monocentric study assessing the efficacy and safety of natural Pterostilbene (Pterocarpus marsupium) for skin brightening and antiaging effects.

Clinical, Cosmetic and Investigational Dermatology 2020:13 105–116.

The anti-aging and skin brightening effect of pTeroWhite® cream was demonstrated in an open-label, single-arm, monocentric efficacy study in 38 healthy volunteers who applied a cream containing 0.4% pterostilbene for a period of 8 weeks. The dermatological assessment, together with instrumental and image analysis suggests that pterostilbene effectively brightens skin, improves elasticity, reduces the appearance of fine lines, wrinkles, and improves skin texture as compared to baseline in the subjects studied.

Regular usage of pterostilbene cream resulted in a positive change at all-time points in terms of skin hydration and elasticity in both male and female subjects (Fig. 1). Significant improvement was observed in under-eye fine lines at all-time points and in wrinkles, frown lines, and crow’s feet area at the end of the study (Fig. 2).

Figure 1: Skin hydration assessment by Corneometer for forehead and cheek at week 2 (day 15), week 4 (day 30) vs baseline all p<0.0001
Figure 2: Cutometer assessment of Skin elasticity
(A) Gross Elasticity : Week 4 vs baseline p<0.0001 and Week 8 vs baseline p<0.0001​
Maximum Amplitude of Elasticity : Week 4 vs baseline p<0.0001 and Week 8 vs baseline p<0.0001​
Net Elasticity : Week 4 vs baseline p<0.0002 and Week 8 vs baseline p<0.0001
Visco Elasticity : Week 4 vs baseline p=0.2933 and Week 8 vs baseline p<0.0235​
Antera: Fine Lines, Wrinkles, Medium, Large and Skin Texture

(B) Skin evaluation of Fine Lines, Wrinkles and Skin Texture using Antera; Fine lines, Medium and large wrinkles, and skin texture: week 4, week 8 vs baseline all p<0.0001

Skin Fairness by Shade Card

(C) Dermatological assessment: Mean value for Shade card assessment for skin fairness: for forehead, cheek, untreated control, Forehead vs Untreated control and cheek vs untreated control at Week 2 vs baseline p=0.9999, week 4 vs baseline p<0.0001, and Untreated control week 2 and week 4 vs baseline p=0.9999

Pterostilbene cream was able to improve the skin luminosity with continuous application. All the study subjects agreed that the test product moisturizes their skin, brightens it, makes them look younger, skin is more firm, and even toned. The study did not show any product-related skin irritation, intolerance, or adverse event. The study concluded that application of pterostilbene cream twice daily for 8 weeks was safe, and improved skin texture tone, and helps in keeping skin moisturized, supple and young.

A randomized study to determine the sun protection factor of natural pterostilbene from Pterocarpus marsupium.

Cosmetics 2020, 7, 16

The effect of pterostilbene as a natural SPF ingredient was demonstrated in a randomized study. A cream formulation containing 0.4% of pterostilbene was evaluated in 12 healthy volunteers as per the ISO 24444:2010 regulations showed SPF value of 6.2±1.30. The cream was found to be safe and non-irritant in a repeated patch test conducted in 25 healthy individuals, prior to the SPF study. The cream showed an SPF of 8.84±0.01, in vitro, while pterostilbene as an ingredient had an SPF value of 21.73±0.06. Further, the study demonstrated the potent antioxidant effects of pterostilbene in various in vitro and cellular test systems. With the status of chemical sunscreens, and the concerns about their systemic absorption and safety, this study has demonstrated pterostilbene as a safe alternative for topical sun-protective formulations.